Biological process  Cell communication ; Signal transduction
 Molecular function  Receptor binding
 
Protein   transforming growth factor, beta 1  Gene symbol   TGFB1
 
 Cellular component  
     
 
Component
Extracellular
 
   
 
Experimental evidence   
  Total number of studies : 14    
 
Peptide sequence Method Platform  Sample  Reference
ELISA - Plasma Shirai et al. 1994
ELISA - Serum Robak et al. 2001
ELISA - Plasma Martin et al. 2007
ELISA - Serum Higashimoto et al. 2008
ELISA - Plasma Grant et al. 2011
Immunoassay - Serum Hughes et al. 2003
Immunoassay - Plasma Haab et al. 2005
Mass spectrometry Q-TOF Plasma Bastos-Amador et al. 2012
Western blot Serum Graner et al. 2008
Mass spectrometry Plasma Liu et al. 2007
Mass spectrometry LTQ linear ion trap Plasma Tu et al. 2005
Mass spectrometry LTQ FT Serum Sennels et al. 2007
Mass spectrometry LTQ FT Plasma Prentice et al. 2010
Mass spectrometry - Plasma Farrah et al. 2011
 
   
 
 Multiple reaction monitoring data  
     
 
Peptide sequence MH+ Sample Number of studies Reference
Data not present
 
   
 
  Protein concentration    
     
 
Protein concentration Method Sample
Reference
2.3  ng/ml Plasma Liu et al. 2005
3.3  ng/ml Spectral counting  Plasma Farrah et al. 2011
4.5  ng/ml Plasma Anderson et al. 2004
14  ng/ml Plasma Polanski et al. 2007
75  ng/ml Immunoassay  Plasma Haab et al. 2005
75  ng/ml Plasma Panchaud et al. 2009
1.4+/-0.8  ng/ml ELISA  Plasma Shirai et al. 1994
11.7-70.6  ng/ml ELISA  Serum Robak et al. 2001
14.98+/-12.39  ng/ml ELISA  Plasma Martin et al. 2007
59.6+/-2.2  ng/ml ELISA  Serum Higashimoto et al. 2008
8.5-34.9  ng/ml Immunoassay  Serum Hughes et al. 2003
 
   
 
  Extracellular vesicle proteins    
     
 
Sample Isolation  Experimental method Vesiclepedia accession Reference
Serum - Brain tumor  Differential centrifugation|Sucrose density gradient  Western blotting  Vesiclepedia_7040 Bastos-Amador et al. 2012 
Plasma  Differential centrifugation|Filtration  FACS|ELISA  Vesiclepedia_7040 Bastos-Amador et al. 2012 
Plasma  Differential centrifugation|Filtration|Ultracenrifugation|Sucrose density gradient  Mass spectrometry [Q-TOF]  Vesiclepedia_7040 Bastos-Amador et al. 2012 
 
   
 
 Architecture  
     
 
Domains Motifs
TGFB   293 - 390
SP   1 - 25
 
   
 
 External links  
     
 
HPRD UniProt NetPath 
01821  P01137  NetPath_M7040 
 
   
 
 
 Protein sequence  NP_000651.3
     
   
    MPPSGLRLLP LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE ADYYAKEVTR VLMVETHNEI
YDKFKQSTHS IYMFFNTSEL REAVPEPVLL SRAELRLLRL KLKVEQHVEL YQKYSNNSWR YLSNRLLAPS DSPEWLSFDV TGVVRQWLSR GGEIEGFRLS AHCSCDSRDN TLQVDINGFT
TGRRGDLATI HGMNRPFLLL MATPLERAQH LQSSRHRRAL DTNYCFSSTE KNCCVRQLYI DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SAAPCCVPQA
LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS