Biological process  Transport  Molecular function  Transporter activity   Protein   transthyretin  Gene symbol   TTR    Cellular component           Component Extracellular         Experimental evidence      Total number of studies : 52       Peptide sequence Method Platform  Sample  Reference Immunoassay - Plasma Haab et al. 2005 Mass spectrometry LTQ Plasma Looze et al. 2008 Mass spectrometry LTQ Orbitrap Velos Plasma Kalra et al. 2013 Multiple reaction monitoring - Plasma Percy et al. 2012 Multiple reaction monitoring - Plasma Percy et al. 2013 Single radial immunodiffusion - Serum Storiko et al. 1968 Multiple reaction monitoring 6490 QQQ Blood Chambers et al. 2012 Multiple reaction monitoring TSQ Vantage Plasma Huttenhain et al. 2012 Multiple reaction monitoring 4000 QTRAP Plasma Kuzyk et al. 2009 Multiple reaction monitoring 4000 QTRAP Plasma Randall et al. 2010 Multiple reaction monitoring 6490 QQQ Plasma Percy et al. 2013 Mass spectrometry LCQ DecaXP Serum Tirumalai et al. 2003 Mass spectrometry Plasma Liu et al. 2007 Mass spectrometry LCQ Duo Serum Gundry et al. 2007 Mass spectrometry LTQ Orbitrap XL Plasma Bassani-Sternberg et al. 2010 Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Madian et al. 2010 Mass spectrometry QSTAR Pulsar Serum Zhou et al. 2004 Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2010 Mass spectrometry Plasma Zhang et al. 2010 Mass spectrometry LTQ Orbitrap XL Plasma Panchaud et al. 2009 Mass spectrometry LTQ Orbitrap XL Plasma Kang et al. 2010 2-D DIGE - Plasma Corzett et al. 2010 Mass spectrometry MALDI-TOF Plasma Chen et al. 2004 Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2005 Mass spectrometry LTQ linear ion trap Plasma Jin et al. 2005 Mass spectrometry MALDI-TOF Plasma Nedelkov et al. 2005 Mass spectrometry MALDI-TOF/TOF Serum Misek et al. 2005 Mass spectrometry LCQ Deca XP Serum Barnea et al. 2005 Mass spectrometry LTQ linear ion trap Serum He et al. 2005 Mass spectrometry LCQ Deca Plasma Moritz et al. 2005 Mass spectrometry LTQ linear ion trap Plasma Tu et al. 2005 Mass spectrometry - Plasma Michel et al. 2006 Mass spectrometry MALDI-TOF Plasma Yang et al. 2006 Mass spectrometry Finnigan LTQ MS Plasma Okano et al. 2006 Mass spectrometry IMS-TOF Plasma Valentine et al. 2006 Mass spectrometry MALDI-TOF Plasma Manabe et al. 2007 Mass spectrometry Finnigan LTQ MS Plasma Kakisaka et al. 2007 Mass spectrometry LTQ FT Serum Sennels et al. 2007 Mass spectrometry SELDI-TOF Plasma Sihlbom et al. 2008 Mass spectrometry Agilent XCT plus Serum Stempfer et al. 2008 Mass spectrometry LTQ-Orbitrap Plasma Greening et al. 2009 Mass spectrometry Agilent 1100 LC/MSD Trap XCT Plus System Plasma Ahrends et al. 2009 Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Jeong et al. 2010 Mass spectrometry MALDI-TOF Serum Wong et al. 2010 Mass spectrometry MALDI-TOF Plasma Darde et al. 2010 Mass spectrometry LTQ FT Plasma Prentice et al. 2010 Mass spectrometry LTQ Plasma Tu et al. 2010 Mass spectrometry MALDI-TOF Plasma Kolialexi et al. 2010 Mass spectrometry LTQ Orbitrap XL Serum Sinclair et al. 2011 Mass spectrometry - Plasma Farrah et al. 2011 Mass Spectrometry LTQ Plasma Kullolli et al. 2009 Mass spectrometry LCQ Deca XP Plus Plasma/Serum Yang et al. 2005          Multiple reaction monitoring data           Peptide sequence MH+ Sample Number of studies Reference GSPAINVAVHVFR  1366.7  Plasma  2  Percy et al. 2013 AADDTWEPFASGK  1393.6  Plasma  1  Kuzyk et al. 2009 AADDTWEPFASGK  1394.6  Plasma  2  Huttenhain et al. 2012 GSPAINVAVHVFR  1366.7  Plasma  2  Randall et al. 2010 AADDTWEPFASGK  1394.6  Blood  2  Chambers et al. 2012           Protein concentration             Protein concentration Method Sample Reference 109.6  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012 123.88  μg/ml Multiple reaction monitoring  Blood Chambers et al. 2012 260  μg/ml Immunoassay  Plasma Haab et al. 2005 260  μg/ml -  Plasma Panchaud et al. 2009 260  μg/ml -  Plasma Tu et al. 2010 300  μg/ml -  Plasma Wu et al. 2003 300  μg/ml -  Plasma Polanski et al. 2007 315.129  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2013 345  μg/ml -  Plasma Qian et al. 2005 770  μg/ml Spectral counting  Plasma Farrah et al. 2011 100-400  μg/ml Single radial immunodiffusion  Serum Storiko et al. 1968           Extracellular vesicle proteins             Sample Isolation  Experimental method Vesiclepedia accession Reference Plasma - Normal  Filtration|Size exclusion|Sucrose density gradient  Mass spectrometry [LTQ]|Western blotting|Immunoelectron Microscopy  Vesiclepedia_7276 Looze et al. 2008           Architecture           Domains Motifs TRANSTHYR   27 - 147 SP   1 - 20          External links           HPRD UniProt NetPath  01447  P02766  NetPath_M7276             Protein sequence  NP_000362.1               MASHRLLLLC LAGLVFVSEA GPTGTGESKC PLMVKVLDAV RGSPAINVAV HVFRKAADDT WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK ALGISPFHEH AEVVFTANDS GPRRYTIAAL LSPYSYSTTA VVTNPKE