Biological process  Transport
 Molecular function  Transporter activity
 
Protein   apolipoprotein E  Gene symbol   APOE
 
 Cellular component  
     
 
Component
Cytoplasm
Extracellular
 
   
 
Experimental evidence   
  Total number of studies : 49    
 
Peptide sequence Method Platform  Sample  Reference
Immunoassay - Plasma Haab et al. 2005
Mass spectrometry LTQ-Orbitrap Plasma Schenk et al. 2008
Mass spectrometry LTQ Plasma Looze et al. 2008
Mass spectrometry Q-TOF Plasma Bastos-Amador et al. 2012
Mass spectrometry LTQ Orbitrap Velos Plasma Kalra et al. 2013
Multiple reaction monitoring - Plasma Percy et al. 2012
Multiple reaction monitoring TSQ Vantage Plasma Huttenhain et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Randall et al. 2010
Multiple reaction monitoring 4000 QTRAP Plasma Hoofnagle et al. 2012
Multiple reaction monitoring 6490 QQQ Blood Chambers et al. 2012
Multiple reaction monitoring 6490 QQQ Plasma Domanski et al. 2012
Multiple reaction monitoring 6490 QQQ Plasma Percy et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Kuzyk et al. 2009
Multiple reaction monitoring 4000 QTRAP Plasma Barton et al. 2009
Multiple reaction monitoring 4000 QTRAP Serum Kay et al. 2007
Mass spectrometry LCQ DecaXP Serum Tirumalai et al. 2003
Mass spectrometry Plasma Liu et al. 2007
Mass spectrometry LCQ Duo Serum Gundry et al. 2007
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Madian et al. 2010
Mass spectrometry QSTAR Pulsar Serum Zhou et al. 2004
Mass spectrometry LTQ FT Serum Zheng et al. 2006
Mass spectrometry LTQ Orbitrap XL Plasma Madian et al. 2010
Mass spectrometry LCQ Deca XP Plus Serum Adkins et al. 2003
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2010
Mass spectrometry Plasma Zhang et al. 2010
Mass spectrometry LTQ Orbitrap XL Plasma Panchaud et al. 2009
Mass spectrometry LTQ Orbitrap XL Plasma Kang et al. 2010
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2005
Mass spectrometry LTQ linear ion trap Plasma Jin et al. 2005
Mass spectrometry MALDI-TOF Plasma Nedelkov et al. 2005
Mass spectrometry LTQ linear ion trap Serum He et al. 2005
Mass spectrometry LTQ linear ion trap Plasma Tu et al. 2005
Mass spectrometry - Plasma Michel et al. 2006
Mass spectrometry Finnigan LTQ MS Plasma Okano et al. 2006
Mass spectrometry IMS-TOF Plasma Valentine et al. 2006
Mass spectrometry Finnigan LTQ MS Plasma Kakisaka et al. 2007
Mass spectrometry IMS-TOF Plasma Manabe et al. 2007
Mass spectrometry LTQ FT Serum Sennels et al. 2007
Mass spectrometry Finnigan LTQ MS Plasma Dayarathna et al. 2008
Mass spectrometry SELDI-TOF Plasma Sihlbom et al. 2008
Mass spectrometry Agilent 1100 LC/MSD Trap XCT Plus System Plasma Ahrends et al. 2009
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Jeong et al. 2010
Mass spectrometry MALDI-TOF Plasma Darde et al. 2010
Mass spectrometry LTQ FT Plasma Prentice et al. 2010
Mass spectrometry LTQ Plasma Tu et al. 2010
Mass spectrometry LTQ Orbitrap Plasma Shuford et al. 2010
Mass spectrometry LTQ Orbitrap XL Serum Sinclair et al. 2011
Mass spectrometry - Plasma Farrah et al. 2011
Mass spectrometry LCQ Deca XP Plus Plasma/Serum Yang et al. 2005
Mass spectrometry LCQ DECA XP Serum Yang et al. 2004
 
   
 
 Multiple reaction monitoring data  
     
 
Peptide sequence MH+ Sample Number of studies Reference
LGPLVEQGR  967.6  Plasma  Kuzyk et al. 2009
LGPLVEQGR  974.5  Plasma  Domanski et al. 2012
LGPLVEQGR  968.5  Plasma  Domanski et al. 2012
LGPLVEQGR  968.5  Plasma  Percy et al. 2012
LGPLVEQGR  968.5  Blood  Chambers et al. 2012
SELEEQLTPVAEETR  1729.8  Serum  Kay et al. 2007
AATVGSLAGQPLQER  1497.8  Plasma  Huttenhain et al. 2012
SELEEQLTPVAEETR  1730.8  Plasma  Huttenhain et al. 2012
SWFEPLVEDMQR  1536.7  Plasma  Huttenhain et al. 2012
SELEEQLTPVAEETR  1730.8  Plasma  Hoofnagle et al. 2012
LAVYQAGAR  948.5  Plasma  Hoofnagle et al. 2012
SELEEQLTPVAEETR  1730.8  Plasma  Barton et al. 2009
LAVYQAGAR  948.5  Plasma  Randall et al. 2010
LGPLVEQGR  968.5  Plasma  Randall et al. 2010
SELEEQLTPVAEETR  1730.8  Plasma  Randall et al. 2010
LQAEAFQAR  1033.5  Plasma  Randall et al. 2010
AATVGSLAGQPLQER  1497.8  Plasma  Randall et al. 2010
VQAAVGTSAAPVPSDNH  1620.7  Plasma  Randall et al. 2010
 
   
 
  Protein concentration    
     
 
Protein concentration Method Sample
Reference
7.518  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
8  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
8.067  μg/ml Multiple reaction monitoring  Plasma Domanski et al. 2012
14  μg/ml Spectral counting  Plasma Farrah et al. 2011
27.1  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
34  μg/ml Immunoassay  Plasma Haab et al. 2005
34  μg/ml Plasma Panchaud et al. 2009
35  μg/ml Plasma Wu et al. 2003
35  μg/ml Plasma Qian et al. 2005
35  μg/ml Plasma Tu et al. 2010
40  μg/ml Plasma Anderson et al. 2004
40  μg/ml Plasma Gundry et al. 2007
8220  μg/ml Multiple reaction monitoring  Blood Chambers et al. 2012
 
   
 
  Extracellular vesicle proteins    
     
 
Sample Isolation  Experimental method Vesiclepedia accession Reference
Plasma - Normal  Filtration|Size exclusion|Sucrose density gradient  Mass spectrometry [LTQ]|Western blotting|Immunoelectron Microscopy  Vesiclepedia_348 Bastos-Amador et al. 2012 
Plasma  Differential centrifugation|Filtration|Ultracenrifugation|Sucrose density gradient  Mass spectrometry [Q-TOF]  Vesiclepedia_348 Bastos-Amador et al. 2012 
 
   
 
 Architecture  
     
 
Domains Motifs
CC   73 - 101
CC   154 - 186
CC   233 - 282
SP   1 - 18
 
   
 
 External links  
     
 
HPRD UniProt NetPath 
00135  P02649  NetPath_M348 
 
   
 
 
 Protein sequence  NP_000032.1
     
   
    MKVLWAALLV TFLAGCQAKV EQAVETEPEP ELRQQTEWQS GQRWELALGR FWDYLRWVQT LSEQVQEELL SSQVTQELRA LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA
RLGADMEDVC GRLVQYRGEV QAMLGQSTEE LRVRLASHLR KLRKRLLRDA DDLQKRLAVY QAGAREGAER GLSAIRERLG PLVEQGRVRA ATVGSLAGQP LQERAQAWGE RLRARMEEMG
SRTRDRLDEV KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK VQAAVGTSAA PVPSDNH