Biological process  Transport
 Molecular function  Transporter activity
 
Protein   apolipoprotein A-IV  Gene symbol   APOA4
 
 Cellular component  
     
 
Component
Extracellular
 
   
 
Experimental evidence   
  Total number of studies : 47    
 
Peptide sequence Method Platform  Sample  Reference
ELISA - Plasma Kondo et al. 1989
ELISA - Plasma Kronenberg et al. 2000
ELISA - Plasma Dieplinger et al. 2009
Mass spectrometry Q-TOF Plasma Bastos-Amador et al. 2012
Multiple reaction monitoring - Plasma Percy et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Randall et al. 2010
Multiple reaction monitoring 4000 QTRAP Plasma Barton et al. 2009
Multiple reaction monitoring 4000 QTRAP Serum Kay et al. 2007
Multiple reaction monitoring 6490 QQQ Blood Chambers et al. 2012
Multiple reaction monitoring 6490 QQQ Plasma Domanski et al. 2012
Multiple reaction monitoring 6490 QQQ Plasma Percy et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Kuzyk et al. 2009
Mass spectrometry LCQ DecaXP Serum Tirumalai et al. 2003
Mass spectrometry LTQ FT Serum Zheng et al. 2006
Mass spectrometry LTQ Orbitrap XL Plasma Madian et al. 2010
Mass spectrometry Plasma Zhang et al. 2010
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2010
Mass spectrometry LTQ Orbitrap XL Plasma Panchaud et al. 2009
2-DE Plasma Bandow et al. 2010
Mass spectrometry 6340 Ion Trap LC/MS Plasma Zhang et al. 2008
Mass spectrometry LTQ Orbitrap XL Plasma Kang et al. 2010
2-D DIGE - Plasma Corzett et al. 2010
Mass spectrometry MALDI-TOF Plasma Chen et al. 2004
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2005
Mass spectrometry MALDI-TOF/TOF Serum Misek et al. 2005
Mass spectrometry LCQ Deca XP Serum Barnea et al. 2005
Mass spectrometry LTQ linear ion trap Serum He et al. 2005
Mass spectrometry LCQ Deca Plasma Moritz et al. 2005
Mass spectrometry LTQ linear ion trap Plasma Tu et al. 2005
Mass spectrometry - Plasma Michel et al. 2006
Mass spectrometry MALDI-TOF Plasma Yang et al. 2006
Mass spectrometry Finnigan LTQ MS Plasma Okano et al. 2006
Mass spectrometry IMS-TOF Plasma Valentine et al. 2006
Mass spectrometry IMS-TOF Plasma Manabe et al. 2007
Mass spectrometry LTQ FT Serum Sennels et al. 2007
Mass spectrometry Finnigan LTQ MS Plasma Dayarathna et al. 2008
Mass spectrometry SELDI-TOF Plasma Sihlbom et al. 2008
Mass spectrometry Agilent 1100 LC/MSD Trap XCT Plus System Plasma Ahrends et al. 2009
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Kolla et al. 2009
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Jeong et al. 2010
Mass spectrometry MALDI-TOF Plasma Darde et al. 2010
Mass spectrometry LTQ Plasma Tu et al. 2010
Mass spectrometry LTQ Orbitrap Plasma Shuford et al. 2010
Mass spectrometry MALDI-TOF/TOF Plasma Bortner et al. 2010
Mass spectrometry LTQ Orbitrap XL Serum Sinclair et al. 2011
Mass spectrometry 4800 Proteomics Analyzer Plasma Bouwman et al. 2011
Mass spectrometry - Plasma Farrah et al. 2011
 
   
 
 Multiple reaction monitoring data  
     
 
Peptide sequence MH+ Sample Number of studies Reference
SLAPYAQDTQEK  1349.7  Plasma  Kuzyk et al. 2009
SLAPYAQDTQEK  1356.6  Plasma  Domanski et al. 2012
SLAPYAQDTQEK  1350.6  Plasma  Domanski et al. 2012
SLAPYAQDTQEK  1350.6  Plasma  Percy et al. 2012
SLAPYAQDTQEK  1350.6  Blood  Chambers et al. 2012
LGEVNTYAGDLQK  1406.8  Serum  Kay et al. 2007
LGEVNTYAGDLQK  1407.7  Plasma  Barton et al. 2009
SLAELGGHLDQQVEEFR  1927.9  Plasma  Randall et al. 2010
ISASAEELR  975.5  Plasma  Randall et al. 2010
LAPLAEDVR  983.5  Plasma  Randall et al. 2010
VNSFFSTFK  1076.5  Plasma  Randall et al. 2010
IDQNVEELK  1087.5  Plasma  Randall et al. 2010
IDQTVEELR  1102.5  Plasma  Randall et al. 2010
SLAPYAQDTQEK  1350.6  Plasma  Randall et al. 2010
LGEVNTYAGDLQK  1407.7  Plasma  Randall et al. 2010
SELTQQLNALFQDK  1634.8  Plasma  Randall et al. 2010
 
   
 
  Protein concentration    
     
 
Protein concentration Method Sample
Reference
32  μg/ml Spectral counting  Plasma Farrah et al. 2011
35.8  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
49.54  μg/ml Multiple reaction monitoring  Blood Chambers et al. 2012
160  μg/ml Plasma Anderson et al. 2004
160  μg/ml Plasma Gundry et al. 2007
143-158  μg/ml ELISA  Plasma Kronenberg et al. 2000
16.4+/-5.4  mg/dl ELISA  Plasma Kondo et al. 1989
19.7  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
23.872  μg/ml Multiple reaction monitoring  Plasma Domanski et al. 2012
35  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
55-340  μg/ml ELISA  Plasma Dieplinger et al. 2009
 
   
 
  Extracellular vesicle proteins    
     
 
Sample Isolation  Experimental method Vesiclepedia accession Reference
Plasma  Differential centrifugation|Filtration|Ultracenrifugation|Sucrose density gradient  Mass spectrometry [Q-TOF]  Vesiclepedia_337 Bastos-Amador et al. 2012 
 
   
 
 Architecture  
     
 
Domains Motifs
ERM   70 - 314
CC   369 - 387
CC   84 - 114
CC   227 - 268
SP   1 - 21
 
   
 
 External links  
     
 
HPRD UniProt NetPath 
00130  P06727  NetPath_M337 
 
   
 
 
 Protein sequence  NP_000473.2
     
   
    MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ KSELTQQLNA LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE EIGKELEELR ARLLPHANEV
SQKIGDNLRE LQQRLEPYAD QLRTQVSTQA EQLRRQLTPY AQRMERVLRE NADSLQASLR PHADELKAKI DQNVEELKGR LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG
LTFQMKKNAE ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK VNSFFSTFKE
KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES