Biological process  Cell communication ; Signal transduction
 Molecular function  Peptide hormone
 
Protein   angiotensinogen (serpin peptidase inhibitor, clade A, member 8)  Gene symbol   AGT
 
 Cellular component  
     
 
Component
Extracellular
 
   
 
Experimental evidence   
  Total number of studies : 38    
 
Peptide sequence Method Platform  Sample  Reference
Mass spectrometry LTQ-Orbitrap Plasma Schenk et al. 2008
Mass spectrometry LTQ Plasma Looze et al. 2008
Mass spectrometry Q-TOF Plasma Bastos-Amador et al. 2012
Multiple reaction monitoring - Plasma Percy et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Randall et al. 2010
Multiple reaction monitoring 6490 QQQ Blood Chambers et al. 2012
Multiple reaction monitoring 6490 QQQ Plasma Domanski et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Kuzyk et al. 2009
Mass spectrometry LCQ DecaXP Serum Tirumalai et al. 2003
Mass spectrometry Plasma Liu et al. 2007
Mass spectrometry LCQ Duo Serum Gundry et al. 2007
Mass spectrometry LCQ Deca XP Plus Plasma Gong et al. 2006
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2010
Mass spectrometry LTQ Orbitrap XL Plasma Panchaud et al. 2009
Mass spectrometry LTQ Orbitrap XL Plasma Yadav et al. 2011
Mass spectrometry LTQ Orbitrap XL Plasma Kang et al. 2010
2-D DIGE - Plasma Corzett et al. 2010
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2005
Mass spectrometry LTQ linear ion trap Plasma Jin et al. 2005
Mass spectrometry LCQ Deca XP Serum Barnea et al. 2005
Mass spectrometry LTQ linear ion trap Serum He et al. 2005
Mass spectrometry LCQ Deca Plasma Moritz et al. 2005
Mass spectrometry LTQ linear ion trap Plasma Tu et al. 2005
Mass spectrometry - Plasma Michel et al. 2006
Mass spectrometry Finnigan LTQ MS Plasma Okano et al. 2006
Mass spectrometry IMS-TOF Plasma Valentine et al. 2006
Mass spectrometry LTQ FT Serum Sennels et al. 2007
Mass spectrometry Finnigan LTQ MS Plasma Dayarathna et al. 2008
Mass spectrometry Agilent 1100 LC/MSD Trap XCT Plus System Plasma Ahrends et al. 2009
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Jeong et al. 2010
Mass spectrometry LTQ FT Plasma Prentice et al. 2010
Mass spectrometry LTQ Plasma Tu et al. 2010
Mass spectrometry LTQ Orbitrap Plasma Shuford et al. 2010
Mass spectrometry 1100 Series LC/MSD Trap XCT Ultra ion trap Plasma Kaur et al. 2010
Mass spectrometry MALDI-TOF/TOF Plasma Bortner et al. 2010
Mass spectrometry LTQ Orbitrap XL Serum Sinclair et al. 2011
Mass spectrometry - Plasma Farrah et al. 2011
Mass spectrometry LCQ Deca XP Plus Plasma/Serum Yang et al. 2005
 
   
 
 Multiple reaction monitoring data  
     
 
Peptide sequence MH+ Sample Number of studies Reference
ALQDQLVLVAAK  1267.8  Plasma  Kuzyk et al. 2009
ALQDQLVLVAAK  1274.7  Plasma  Domanski et al. 2012
ALQDQLVLVAAK  1268.7  Plasma  Domanski et al. 2012
ALQDQLVLVAAK  1268.7  Blood  Chambers et al. 2012
SLDFTELDVAAEK  1437.7  Plasma  Randall et al. 2010
VLSALQAVQGLLVAQGR  1723  Plasma  Randall et al. 2010
DPTFIPAPIQAK  1297.7  Plasma  Randall et al. 2010
QPFVQGLALYTPVVLPR  1898  Plasma  Randall et al. 2010
 
   
 
  Protein concentration    
     
 
Protein concentration Method Sample
Reference
1  ng/ml Plasma Liu et al. 2005
1.5  μg/ml Serum Gundry et al. 2007
10.548  μg/ml Multiple reaction monitoring  Plasma Domanski et al. 2012
11  μg/ml Spectral counting  Plasma Farrah et al. 2011
45  μg/ml Plasma Wu et al. 2003
45  μg/ml Plasma Qian et al. 2005
45  μg/ml Plasma Tu et al. 2010
47.6  μg/ml Multiple reaction monitoring  Plasma Percy et al. 2012
60.63  μg/ml Multiple reaction monitoring  Blood Chambers et al. 2012
1.5  μg/ml Plasma Anderson et al. 2004
150-2500  pg/ml serum Adkins et al. 2003
 
   
 
  Extracellular vesicle proteins    
     
 
Sample Isolation  Experimental method Vesiclepedia accession Reference
Plasma - Normal  Filtration|Size exclusion|Sucrose density gradient  Mass spectrometry [LTQ]|Western blotting|Immunoelectron Microscopy  Vesiclepedia_183 Bastos-Amador et al. 2012 
Plasma  Differential centrifugation|Filtration|Ultracenrifugation|Sucrose density gradient  Mass spectrometry [Q-TOF]  Vesiclepedia_183 Bastos-Amador et al. 2012 
 
   
 
 Architecture  
     
 
Domains Motifs
SERPIN   99 - 481
SP   1 - 34
 
   
 
 External links  
     
 
HPRD UniProt NetPath 
00106  P01019  NetPath_M183 
 
   
 
 
 Protein sequence  NP_000020.1
     
   
    MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM
HSELWGVVHG ATVLSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD
FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT
FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN
PLSTA