Biological process  Protein metabolism
 Molecular function  Binding
 
Protein   amyloid P component, serum  Gene symbol   APCS
 
 Cellular component  
     
 
Component
Cytoplasm
Extracellular
Nucleus
 
   
 
Experimental evidence   
  Total number of studies : 41    
 
Peptide sequence Method Platform  Sample  Reference
ELISA - Serum Adachi et al. 1996
ELISA - Serum Bijl et al. 2004
Mass spectrometry Q-TOF Plasma Bastos-Amador et al. 2012
Mass spectrometry LTQ Orbitrap Velos Plasma Kalra et al. 2013
Multiple reaction monitoring - Plasma Percy et al. 2013
Multiple reaction monitoring 6490 QQQ Plasma Percy et al. 2013
Multiple reaction monitoring Xevo TQ MS Plasma Heywood et al. 2012
Multiple reaction monitoring 4000 QTRAP Plasma Kuzyk et al. 2009
Mass spectrometry LTQ Orbitrap Serum Zeng et al. 2011
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2010
Mass spectrometry LTQ Orbitrap XL Plasma Panchaud et al. 2009
Mass spectrometry 6340 Ion Trap LC/MS Plasma Zhang et al. 2008
Mass spectrometry LTQ Orbitrap XL Plasma Kang et al. 2010
2-D DIGE - Plasma Corzett et al. 2010
Mass spectrometry Fourier transform ion cyclotron resonance (FT_ICR) Plasma Qian et al. 2005
Mass spectrometry MALDI-TOF Plasma Nedelkov et al. 2005
Mass spectrometry MALDI-TOF/TOF Serum Misek et al. 2005
Mass spectrometry LCQ Deca XP Serum Barnea et al. 2005
Mass spectrometry LTQ linear ion trap Serum He et al. 2005
Mass spectrometry LTQ linear ion trap Plasma Tu et al. 2005
Mass spectrometry - Plasma Michel et al. 2006
Mass spectrometry Finnigan LTQ MS Plasma Okano et al. 2006
Mass spectrometry IMS-TOF Plasma Valentine et al. 2006
Mass spectrometry Finnigan LTQ MS Plasma Kakisaka et al. 2007
Mass spectrometry Q-TOF Plasma Kim et al. 2007
Mass spectrometry LTQ FT Serum Sennels et al. 2007
Mass spectrometry Finnigan LTQ MS Plasma Dayarathna et al. 2008
Mass spectrometry SELDI-TOF Plasma Sihlbom et al. 2008
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Kolla et al. 2009
Mass spectrometry 4800 Plus MALDI TOF/TOF Plasma Jeong et al. 2010
Mass spectrometry MALDI-TOF Plasma Darde et al. 2010
Mass spectrometry LTQ FT Plasma Prentice et al. 2010
Mass spectrometry LTQ Plasma Tu et al. 2010
Mass spectrometry LTQ Orbitrap Plasma Shuford et al. 2010
Mass spectrometry LTQ Plasma Nakshatri et al. 2010
Mass spectrometry MALDI-TOF/TOF Plasma Bortner et al. 2010
Mass spectrometry LTQ Orbitrap XL Serum Sinclair et al. 2011
Mass spectrometry 4800 Proteomics Analyzer Plasma Bouwman et al. 2011
Mass spectrometry - Plasma Farrah et al. 2011
Mass spectrometry LCQ Deca XP Plus Plasma/Serum Yang et al. 2005
Mass spectrometry LCQ DECA XP Serum Yang et al. 2004
 
   
 
 Multiple reaction monitoring data  
     
 
Peptide sequence MH+ Sample Number of studies Reference
IVLGQEQDSYGGK  1393.6  Plasma  Percy et al. 2013
VGEYSLYIGR  1155.6  Plasma  Kuzyk et al. 2009
VGEYSLYIGR  1156.6  Plasma  Heywood et al. 2012
 
   
 
  Protein concentration    
     
 
Protein concentration Method Sample
Reference
8.7  μg/ml Spectral counting  Plasma Farrah et al. 2011
55  μg/ml Plasma Wu et al. 2003
55  μg/ml Plasma Qian et al. 2005
55  μg/ml Plasma Tu et al. 2010
1402  ng/ml Multiple reaction monitoring  Plasma Percy et al. 2013
27.7+/-10.6  mg/l ELISA  Serum Bijl et al. 2004
10-15  μg/ml ELISA  Serum Adachi et al. 1996
 
   
 
  Extracellular vesicle proteins    
     
 
Sample Isolation  Experimental method Vesiclepedia accession Reference
Plasma  Differential centrifugation|Filtration|Ultracenrifugation|Sucrose density gradient  Mass spectrometry [Q-TOF]  Vesiclepedia_325 Bastos-Amador et al. 2012 
 
   
 
 Architecture  
     
 
Domains Motifs
PTX   20 - 223
SP   1 - 19
 
   
 
 External links  
     
 
HPRD UniProt NetPath 
00101  P02743  NetPath_M325 
 
   
 
 
 Protein sequence  NP_001630.1
     
   
    MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS
SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV